Table 1 Representative Fenton- and Fenton-like reaction-based nanomaterials and their typical applications in cancer theranostics
Nanomaterials | Fenton nanoagents | Applications | Refs. |
|---|---|---|---|
Iron-based nanomaterials | Dichloroacetic acid@MOF-Fe2+ | CDT | [48] |
DOX-ferrocene-inhibitor@β-CD NPs | CDT-chemotherapy | [49] | |
DOX@Pt prodrug-Fe3+ NPs | CDT-chemotherapy | [50] | |
Fe3O4/triphenylphosphine/PpIX NPs | CDT-PDT | [51] | |
PtFe@Fe3O4 NPs | CDT-PTT | [52] | |
Fe-porphyrin@Bis(DPA-Zn)-RGD/(SOD2)-siRNA NPs | CDT-SDT | [19] | |
Hollow Fe3O4 mesocrystals NPs | CDT-MHT | [53] | |
Zero-valence iron-polyvinyl pyrrolidone NPs | CDT-MHT-PTT | [54] | |
Fe-MIL-100/GOD@HA-PDA NPs | All-in-one agent | [55] | |
Mn-based nanomaterials | Thiol-functionalized MSN NPs@MnO2 NPs | CDT | [56] |
Bufalin@hollow MnO2 NPs | CDT-chemotherapy | [57] | |
Mn-carbon dots NPs | CDT-PDT | [58] | |
Mn-Gd2O3@PDA NPs | CDT-PTT | [59] | |
PpIX@hollow mesoporous organosilica-MnOx-RGD NPs | CDT-SDT | [60] | |
Hollow MnO2-DOX-GOD-HA NPs | All-in-one agent | [61] | |
Cu-based nanomaterials | Cu-TCPP MOF | CDT | [62] |
Hollow mesoporous silica-Cu-GOD NPs | CDT-chemotherapy | [63] | |
Cu2Se hollow nanocubes-PEG | CDT-PTT | [64] | |
Cu-5,10,15,20-tetrabenzoatoporphyrin nMOF and anti-PDL-1 | CDT-PDT-immunotherapy | [65] | |
Ce6@Cu-MOF NPs | CDT-SDT | [66] | |
GOD@hollow mesoporous Cu2MoS4 NPs | All-in-one agent | [46] | |
Other metal-based nanomaterials | TiO2-ruthenium(II) complexe NPs | CDT | [67] |
MoS2@GOD-tirapazamine-chitosan NPs | CDT-chemotherapy | [68] | |
ZIF-67-DOX@PpIX@ZIF-8@PDA NPs | CDT-PDT-chemotherapy | [69] | |
WO3-x@γ-Poly-L-glutamic acid NPs | CDT-PTT | [70] | |
TiO1+x-PEG NPs | CDT-SDT | [71] | |
Au2Pt -Ce6-PEG NPs | All-in-one agent | [72] |