Fig. 3

a Timeline of the PEG-GNRs injection and toxicity evaluations in rats. b The blood markers test of mice treated with PEG-GNRs (injected doses from left to right: 0 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg) at 3 days, 1 week, 2 weeks after treatment. In each histogram, the light gray regions represent the normal range according to the literature. RBC red blood cell, WBC white blood cell, PLT platelet, ALP alkaline phosphatase, TPROT total protein, ALB albumin, TBIL total bilirubin, AST aspartate transaminase, ALT alanine transaminase, BUN blood urea nitrogen, CRE creatinine. c The remaining Au in blood after PEG-GNRs injection. d The biodistribution at 3 days, 1 week, 2 weeks after systemic administration of 10 mg/kg PEG-GNRs in rats. e H&E staining photographs of major organs in rats 2 weeks after the treatment. Images were acquired at 200 × magnification