Fig. 4

a Timeline of the PEG-GNRs injection and toxicity evaluations in Macaca fascicularis. b Blood test results. Times after injection in the figures from left to right are 1 h, 2 h, 6 h, 12 h, 1 d, 2 d, 3 d, 1 w, 2 w, 3 w, 4 w, 5 w, 6 w, 7 w, 8 w, 9 w, 10 w, 11 w, and 12 w. The light gray boxes indicate literature reference values, and the gray boxes indicate the control group in our test. c Blood circulation time of PEG-GNRs analyzed by measuring the remaining Au content in blood. d The biodistribution of PEG-GNRs in different organs at 12 weeks after treatment. e Histological images of the major organs of the control and experimental animal #1 (number 1) 12 weeks post-injection with PEG-GNRs. Images were acquired at 200 × magnification