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Fig. 12 | Journal of Nanobiotechnology

Fig. 12

From: Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

Fig. 12

Pregnancy exposure to TiO2NPs caused the disruption of gut-brain associated immune response but did not affect the levels of enteric neuron and gut-derived neurotransmitters and peptides in offspring. After designed treatment, the indicators were assessed at postnatal day (PD) 10, 21 and 49, respectively. A-B Effects of TiO2NPs on sIgA and DAO contents in gut were determined by using ELISA assay. The HuC/D and TuJ1 expressions were determined by immunofluorescence staining, and the representative images were shown in (C) and (D). Scale bar, 50 μm. E–F Effects of TiO2NPs on the Hrt3a and Hrt4 mRNA expressions in the cortex. Data were presented as mean ± S.E.M. Statistical analysis was performed by using repeated-measure ANOVA or independent student t test or Mann–Whitney U test

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Journal of Nanobiotechnology

ISSN: 1477-3155

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