Fig. 10
In vivo antitumor effects of normal saline and drug-loaded preparations intravenously administered to tumor-bearing BALB/c nude mice once every 2 days for 12 days. Doses: PTX, 5 mg/kg; IR780, 1 mg/kg. Normal saline: Saline, control. A Images of tumors, tumor volume changes, and tumor weights at the end of the 13-day treatment period. B Micrographs of tumor tissue slices for proliferating cell nuclear antigen (PCNA) and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) analysis. C Western blotting for apoptosis-related proteins (n = 5). For the phototherapy group, animals were exposed to NIR at 808 nm (1 W/cm2) for 5 min 2 h post-drug administration. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05