Fig. 8
Circulation of nanoparticles in vivo. A In vivo pharmacokinetic properties of PTX, and the biodistribution of PTX and IR780 following intravenous administration of PTX and IR780 co-loaded preparations in rats. The doses of PTX and IR780 were 5 mg/kg and 1 mg/kg, respectively (n = 6). B Results of crown protein analysis via sodium dodecyl sulfate-polyacrylamide gel electrophoresis. C Bubble map of the top 15 entries from a Gene Ontology (GO) enrichment analysis. The GO entries were screened for differential proteins with scores greater than 1 in the three categories. Then, the top 5 corresponding −log10 p-values were obtained from each entry. Entries with larger bubbles indicate more proteins. Color change from yellow to red suggests that the enrichment p-value is smaller and the significant difference is greater. NS, not significant; p > 0.05; *p < 0.05, **p < 0.01