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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Fig. 5

dECM@exo modulated pyroptosis in NPCs. A Fluorescence images of GSDMD after IL-1β + TNF-α stimulation in the NC, IL, dECM, Exo and dECM@exo groups. Scale bar = 50 μm. B Quantitative analysis of the fluorescence intensity of GSDMD in each group. The data are presented represent as the mean ± SD (n = 4). *P < 0.05. C Protein expression levels of NLRP3, cleaved Caspase-1, NT-GSDMD, and IL-1β. D–G Quantification of protein expression. GAPDH served as a loading control. Data are presented as the mean ± SD (n = 3). *P < 0.05 vs. the IL group

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Journal of Nanobiotechnology

ISSN: 1477-3155

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