Fig. 6

Tubular HA-collagen nanofibers accelerated urethral reconstruction at wound site on week 16 after implantation. A The urinary flow rate of the collagen group and HA-collagen group at each predetermined time point after implantation, n = 3. B Representative voiding cystourethrography of each group on week 16 after implantation. The yellow square areas indicate the position of urethral regeneration. Urocystography of a healthy animal without a urethral graft was used as control sample. The black arrow indicates the discharged contrast agent. Representative C HE, D Masson’s trichrome, and E VVG staining micrographs of the health and regenerated urethras on week 16. The black square areas in C (the upper panel) were enlarged in D, E (the lower panel) at 20\(\times\). Scale bars: C 350 μm; D, E 20 μm. Black triangles indicate the location of the degraded nanofibrous scaffold, yellow triangles indicate the blood vessels