Fig. 5

A mesoporous silica nanoparticle (MSN)-based approach (Cur@MSN-RhoG/TAT) for neurodegenerative therapy. Non-covalent binding of nanoparticles, cell penetrating peptides (TAT), gene(Plasmid RhoG) and drug(Curcumin) (A). TEM image of MSN (B). Therapeutic effffect of Cur@MSN-RhoG/TAT on neurite growth. Morphological images after 4 days of treatment with and without PQ (paraquat, generator of superoxide anion radicals, 150 μM), RA (Retinoic acid, promote neuronal difffferentiation and neurite outgrowth, 20 μM), and Cur@MSN-RhoG/TAT (256 μg/mL). Reprinted with permission from ref. [119] Copyright (2019) American Chemical Society