Nanomaterial | Synthesis of nanomaterial | Cargo | Modification | Pharmacological action | Therapeutic use | Refs. | |
---|---|---|---|---|---|---|---|
Carbon dots | Solvothermal method | – | Nitrogen (N)- containing polyaromatic | Modulating Cu(II)-mediated β-amyloid aggregation | AD | [170] | |
PLGA | Solvent evaporation method | Doxorubicin/lapatinib | ACUPA and cyclic TT1 | Synergistic anti-tumor | Breast cancer brain metastases | [171] | |
Carboxylic acid functionalized carbon dots | Acidic oxidation method | Epirubicin and temozolomide | Transferrin | Synergistic anti-tumor | Glioblastoma | [172] | |
TPGS-transfersomes | Thin-film hydration method | Docetaxel | Folate | Inhibits cell division and proliferation | Glioblastoma | [173] | |
Lipid-coating mesoporous silica nanoparticle | Stobber method and film hydration method | Paclitaxel | Angiopep-2 | Inhibits cell division and proliferation | Glioma | [174] | |
Polyamidoamine dendrimer | Commercially available | Heme oxygenase-1 (HO-1) gene | Histidine and arginine | Anti-inflammatory and anti-apoptotic | Ischemic stroke | [175] | |
Graphene oxide | Modifified Hummers’ method | – | – | Inhibits amyloid beta fifibrillation | Neurodegenerative diseases | [176] | |
Mesoporous silica nanoparticle | Templating method | Curcumin and chrysin | – | Antioxidant | Neurodegenerative diseases | [177] | |
Black phosphorus | Liquid phase exfoliation method | Paeoniflorin | Lactoferrin | Attenuate deficits in tyrosine hydroxylase-positive (TH +) neuronal | PD | [178] | |
Selenium nanoparticles | Chemical reduction method | – | OX26 | Regulate cellular metabolic state | Stroke | [179] | |
Nanostructured lipid carriers | Emulsifification and solvent evaporation method | Baicalin and Salvianolic acid B | OX26 | Oxygen–glucose deprivation | Stroke | [180] | |
Fe3O4 | Solvothermal method | – | PEG | Ameliorate local redox state and facilitate blood − brain-barrier recovery | Stroke | [181] |