Table 3 Cell-Penetrating Peptides modified nanoparticles for CNS diseases

TGN-NP

TGN

TGNYKALHPHNG

 –

PEG-PLGA nanoparticles

 –

bEnd.3

Nude mice, ICR mice

Glioma

[182]

AsTNP

TGN

TGNYKALHPHNG

AS1411

PEG-PCL nanoparticles

Docetaxel

C6, bEnd.3

C6 bearing mice

Glioma

[141]

Tf-PFV-Lip

PFV

PFVYLI

Tf

Liposomes

Doxorubicin, Erlotinib

In vitro BBB model, 3D tumor model

–

Glioma

[183]

ILNPs

IL-13p

TAMRAVDKLLLHLKKLFREGQFNRNFESIIICRDRT

 –

Liposomes

Docetaxel

U87, HUVEC, 3D tumor model

U87 bearing mice

Glioma

[140]

cFd-Lip

dNP2

KIKKVKKKGRKKIKKVKKKGRK-cys

Folic acid (FA)

Liposomes

Paclitaxel

4T1, NIH

3T3,

bEnd.3, 3D tumor model

Breast tumor bearing mice, breast cancer brain metastasis models

Breast cancer and brain metastasis

[184]

cFd-Lip

dNP2

KIKKVKKKGRKKIKKVKKKGRK-cys

FA

Liposomes

Paclitaxel

bEnd.3, C6

C6 bearing mice

Glioma

[185]

MT1-NP

MT1-AF7p

HWKHLHNTKTFLC

iRGD

PEG-PLA nanoparticles

Paclitaxel

C6

C6 bearing mice

Glioma

[186]

CNP, ANP

CPP,

ACPP

CRRRRRRRRR,

EEEEEEEEC6GSGRSAGRRRRRRRRC6C

 –

Nanoparticles

Paclitaxel

C6

C6 bearing mice

Glioma

[187]

DGL-PEG-LNP

NoLS

KKRTLRKNDRKKRC

 –

Nanoparticles

Plasmid DNA encoding inhibitor of

growth 4 (ING4)

BCEC

U87 bearing mice

Glioma

[33]

RGE-LS

RGERPPR

RGERPPR

 –

Liposomes

Doxorubicin

U87

U87 bearing mice,

Glioma

[188]

TBCNT@OXA

TAT

 YGRKKRRQRRR

 –

Carbon nanotube

Oxaliplatin

HBMEC, C6

C6 bearing mice

Glioma

[189]

TR-Lip

TR

c(RGDfK)-

AGYLLGHINLHHLAHL(Aib)HHIL-Cys

 –

Liposomes

Paclitaxel

C6, bEnd.3, CSCs

C6 bearing mice

Glioma

[190]

RGE-PEG / PGG-PTX NPs

RGERPPR

RGERPPR

 –

Nanoparticles

polymer-drug conjugates (PGG-PTX)

U87, HUVECs

U87 bearing mice

Glioma

[191]

pSiNPs

SIWV

SIWV

 –

Nanoparticles

SN-38

U87

U87 bearing mice

Glioma

[192]

Tf-Pen lip

Pen

RQIKIWFQNRRMKWKK

Tf

Liposomes

Doxorubicin, Erlotinib

U87, bEnd.3

U87 bearing mice

Glioma

[193]

Tf-Pen lip

Pen

RQIKIWFQNRRMKWKK

Tf

Liposomes

5-Fluorouracil

U87, bEnd.3

U87 bearing mice

Glioma

[194]

iNGR-SSL

iNGR

CC(Acm)RNGRGPDC(Acm)

 –

Liposomes

Doxorubicin

U87, HUVECs

U87 bearing mice

Glioma

[195]

P1NS/TNC-FeLP

P1NS

Cys-GRKKRRQRRRPQ

TN-C

Thermosensitive liposomal

Doxorubicin

bEnd.3, CRL-2299, C8-D1A,

CRL-2541, U87, HTB-14

-

Glioma

[196]

TF-CPP-SSL

CPP

GGRRRRRRRRR-amide

Tf

Liposome

Doxorubicin

C6, HUVECs

C6 bearing mice

Glioma

[197]