Fig. 3

In vitro release of free CYC, TSL-CYC, GTSL-CYC and free CYC, TSL-CYC-HER2 and GTSL-CYC-HER2 with or without NIR in pH 7.4 (A–B) and in pH 5.4 (C–D) (*p < 0.05, **p < 0.01). E Degradation behaviors of GTSL-CYC-HER2 irritated without or with NIR. (red arrows indicate gold nanoclusters, black arrows indicate free gold nanoseeds) F Degradation behaviors of GTSL -CYC-HER2 in SBF (a–c) and SLF (d–f) observed by TEM at 0, 24, 48 h. (Red arrows indicate liposome fragments) (a–d: Scale bar = 100 nm. e–f: Scale bar = 50 nm)