Fig. 7
From: Mithramycin delivery systems to develop effective therapies in sarcomas
Transcriptome analysis of cells treated with free and nanocarrier delivered MTM. RNA seq analysis of T-5 H-FC#1 cells treated in triplicate with either DMSO (control), 25 nM free MTM (M_F) or 25 nM MTM-NPs (M_NP) for 24 h. A Principal component analysis of all samples. B–D Volcano plots showing those genes significantly up-regulated and downregulated (fold change ≤-2 or ≥ 2 and padj < 0.01; red dots) when comparing M_NP vs. M_F (B), M_F vs. control (C) and M_NP vs. control (D). Selected genes displaying highly significant p values and/or high fold change modulation are indicated