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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: An atherosclerotic plaque-targeted single-chain antibody for MR/NIR-II imaging of atherosclerosis and anti-atherosclerosis therapy

Fig. 1

Schematic illustration of isolation of ASA6 and its application in imaging and treatment of atherosclerosis. ASA6 are screened from human antibody phage display library based on peripheral blood of CAD patients. ASA6 can specifically bind to Ox-LDL particles to inhibit the uptake of Ox-LDL by macrophages. ASA6 exhibits a therapeutic effect against atherosclerosis in ApoE−/− mice. Due to the specific binding to atherosclerotic plaques, ASA6 can be used in MR/NIR-II imaging of atherosclerosis by conjugated with NaNdF4@NaGdF4 nanoparticles

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Journal of Nanobiotechnology

ISSN: 1477-3155

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