Fig. 5

MR/NIR-II imaging of atherosclerotic plaque in atherosclerotic mice. A The NIR-II fluorescence imaging at different time points before and after the injection of ASA6-NPs probe in ApoE^−/− mice. B The pseudo-color image of NIR-II imaging at 0 and 90 min after ASA6-NPs probe injection. Close-up views of selected regions with positive signals were indicated. C The aortic arch and abdominal aorta in ApoE^−/− mice and lipid staining with Oil-red O. Yellow arrows indicate the atherosclerotic lesions. D The MRI of various mouse organs (including heart, liver, kidney and abdominal aorta) at different time points after ASA6-NPs injection. White arrows indicate the atherosclerotic lesions. E The dynamic changes of the MRI signals of various organs at different points. F The pseudo-color image of MRI signal in coronal position. White arrows indicate the atherosclerotic plaques. Data represent means ± s.d. from three independent replicates