Fig. 6

HPDAlR showed much more potent prohealing activity than RL-QN15 against skin scald in mice. A Representative images of skin scalds on postoperative days 1, 4, 8, and 12 treated with vehicle (PBS), HPDA (0.1 mg/mL), RL-QN15 (1 nM), and HPDAlR. B Quantitative healing rate curves of skin wounds treated with vehicle (PBS), HPDA (0.1 mg/mL), RL-QN15 (1 nM), and HPDAlR. Data were Mean ± SD from nine mice. ^#P < 0.05, and ^##P < 0.01 indicated statistically significant differences compared to vehicle. ^*P < 0.05, and ^***P < 0.001 indicated statistically significant differences compared to RL-QN15 (Student t-test). C Representative images of histomorphological changes in skin scald wounds on postoperative days 8 and 12. Scalded skin sections were stained with H&E. NE: Neoepidermis; GT: Granular tissue, ES: Eschar, M: Muscle. Scale bar: 250 μm. D and E Quantitative assessment of histological re-epithelialization of epidermis on postoperative days 8 and 12. Data were Mean ± SD from nine mice. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 indicated statistical differences between two groups (Student t-test)