Fig. 8

HPDA up-graded the pro-regenerative ability of RL-QN15 against acute full-thickness injured skin wounds in swine. A Representative images of full-thickness wounds on postoperative days 0, 7, 14, 21, and 28 topically treated with vehicle (PBS), HPDA (0.1 mg/mL), RL-QN15 (250 nM), and HPDA (0.1 mg/mL)lR(250 nM) groups. B Quantitative curves of curative effects of vehicle (PBS), HPDA, RL-QN15, and HPDAlR on full-thickness dorsal skin wounds in swine. Data were Mean ± SD from six wounds (n = 6). *P < 0.05, and *** P < 0.001 indicated statistical differences between two groups (Student t-test). C Representative images of skin wound sections stained with H&E and Masson’s trichrome on postoperative day 28 in vehicle (PBS), HPDA (0.1 mg/mL), RL-QN15 (250 nM), and HPDA (0.1 mg/mL)lR(250 nM) groups. NE, Neoepidermis; GT, Granulation tissue; ES, Eschar. D–E Quantitative analysis of neo-epidermal thickness and collagen positive area on postoperative day 28, respectively. Data were Mean ± SD from six wounds (n = 6). *P < 0.05, ** P < 0.01, ***P < 0.001, and **** P < 0.0001 indicated statistical differences between two groups (Student t-test)