Fig. 7

a In vivo fluorescence images at different time points post-injection of Ti-TCPP MOF, and of various organs and tumors at 12 h post-injection. 1 tumor, 2 heart, 3 liver, 4 spleen, 5 lung and 6 kidney. b In vivo photoacoustic images at different time points post-Ti-TCPP MOF injection. Grayscale images represent ultrasound images, and colored images represent photoacoustic images. c Circulating Ti-TCPP MOF levels after i.v. injection, as assessed via ICP-OES. Ti-TCPP MOF pharmacokinetics followed a two-compartment model (n = 3). d Ti-TCPP MOF biodistribution in BxPC-3 tumor-bearing mice at 8 h post-i.v. injection (n = 3). e Time-dependent distribution of Ti in the primary organs of healthy mice after the i.v. injection of Ti-TCPP MOF (n = 3)