Fig. 6

miR-132 deficiency in sEVs promotes Aβ pathology. A–D Under Aβ treatment, neurons were cotreated with glutamate sEVs and miR-132 mimic-loaded sEVs or GABA sEVs and miR-132 inhibitor-loaded sEVs. Then, cell viability was measured by CCK-8 (A, B) or TUNEL assays (C, D). E, F The mice were co-injected with glutamate sEVs/Ctrl sEVs and agomir-132/agomir ctrl loaded sEVs (E) and GABA sEVs/Ctrl sEVs and antagomir-132/antagomir ctrl (F)-loaded sEVs at every other day for seven consecutive intravenous injections. Then the proportion of TUNEL-positive cells in brain slices was calculated. n = 3. Data are presented as the mean ± SEM, *p < 0.05, **p < 0.01