Fig. 6
From: Celastrol-based nanomedicine promotes corneal allograft survival
CPNM inhibited macrophages recruitment and TLR4 expression in corneal allografts. A HE and immunohistochemical staining of corneal grafts on 8 days after surgery (magnification, ×200). A (a, b) HE stains showing the infiltration of inflammatory cells in the allografts of CGR rats in two groups. Immunohistochemical staining of CD68+ (c, d) and iNOS+ (e, f) cells. Greater numbers of neovascularization, CD68+ macrophages and iNOS+ expression (stained in brown) were observed in the blank control group than in the CPNM treated group. The number of inflammatory cells (g), macrophages (h) and iNOS+ expression cells (i) infiltration was statistically significant. *P < 0.05. B Co-labeling in macrophages (CD68 for red and TLR4 for green) from different groups. Scale bars: 50 μm