Fig. 3

In vivo cancer therapeutic study. a SPECT/CT imaging of mice bearing CFPAC-1 tumors after intratumoral injection of ¹⁷⁷Lu-SPN-GIP and free ¹⁷⁷LuCl₃ at the same radioactivity dose of 1.11 MBq. b The tumor growth curves of mice after indicated treatments. Six groups including saline treated mice (as control), SPN-GIP treated mice with or without laser irradiation (SPN-GIP group and SPN-GIP + Laser), ¹⁷⁷LuCl₃ treated mice (¹⁷⁷LuCl₃), and ¹⁷⁷Lu-SPN-GIP treated mice with or without laser irradiation (¹⁷⁷Lu-SPN-GIP and ¹⁷⁷Lu-SPN-GIP + PTT) were used in this experiment (5 mice for each group). c Photos of tumors collected from different groups of mice at day 21 post-treatment. d H&E staining of tumor slices collected from different groups of mice at day 21 post treatment. Scale bar: 100 µm