Fig. 5
Photothermal profiles and biodistribution of the biomimetic NPs. a The temperature rising profiles of Asp8[H40-TPZ/IR780@(RBC-H)] NPs (IR780: 50 µg mL−1) subjected to the irradiation of 808 nm laser with different power densities for 5 min. b The temperature variation curves of Asp8[H40-TPZ/IR780@(RBC-H)] NPs with different concentrations of IR780 and PBS irradiated with laser. c Infrared imaging photos and d temperature change curves of tumor-bearing mice intravenously injected with normal saline and Asp8[H40-TPZ/IR780@(RBC-H)] NPs with laser irradiation at the power density of 1.0 W cm−2 for 5 min. e Ex vivo the fluorescence images of the separated mandibula and g major organs of tumor-bearing mice at 8 h after injection with normal saline (A), H40-PEG loading DiD NPs (B), H40-DiD@(RBC-H) NPs (C), and Asp8[H40-DiD@(RBC-H)] NPs (D). f Average DiD fluorescence intensities of the separated mandibula and h major organs at 8 h with normal saline and different DiD-labeled NPs. The data are presented the average ± standard deviation (n = 3). *** p < 0.001, ns indicates no significant difference