Fig. 7

Histological analysis after the formulations therapy. a Micro-CT 3D reconstruction images of right part of mandibular from tumor-bearing mice after therapy. b Bone volume of 3D architecture for the right part of mandibular. c Relative bone loss volume of right part of mandibular from tumor-bearing mice after various formulations treatment. d TUNEL staining images of tumor tissues with various formulations treatment (scale bar = 50 μm). e H&E staining images of tumor tissues harvested from the tumor-bearing mice with different therapy. (A: Normal saline, B: Normal saline + Laser, C: TPZ + Laser, D: Asp8[H40-PEG@(RBC-H)] + Laser, E: H40-PEG loading IR780 + Laser, F: H40-TPZ/IR780@(RBC-H) + Laser, and G: Asp8[H40-TPZ/IR780@(RBC-H)] + Laser). **p < 0.01 and *** p < 0.001