Fig. 8

Preliminary biosafety assay of Asp8[H40-TPZ/IR780@(RBC-H)] NPs. a The body weight change curves of nude mice bearing WSU-HN6 tumor after various treatment (n=5, mean ± SD). b–d Main blood biochemical parameters of liver function including ALP, ALT, and AST. e, f Main biochemical parameters of kidney function including BUN and CRE. g H&E staining slices of major organs including heart, liver, spleen, lung, and kidney from each group. The mice without any therapy were as a blank group (scale bar = 20 μm). (A: Normal saline, B: Normal saline + Laser, C: TPZ + Laser, D: Asp8[H40-PEG@(RBC-H)] + Laser, E: H40-PEG loading IR780 + Laser, F: H40-TPZ/IR780@(RBC-H) + Laser, and G: Asp8[H40-TPZ/IR780@(RBC-H)] + Laser). *** p < 0.001