Fig. 6
in vivo SDT efficiency of TIR@siRNA in CT26 tumor-bearing mice. A Fluorescence images of tumor sections processed with SOSG at 12 h after various treatments. Microscope images of tumor sections with immunohistochemical staining of B Nrf2 and C γ-H2AX at 12 h after various treatments. In all above experiments, the doses of IR780 and Nrf2-siRNA were 2.0 and 0.5 mg/kg and the US irradiation conducted at the power of 2.0 W/cm2 for 5 min (1 MHz, 50% duty cycle)