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Fig. 11 | Journal of Nanobiotechnology

Fig. 11

From: Novel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo

Fig. 11

A Schematic diagram of in vivo anti-glioma effect study B Images of brain tissues isolated from orthotopic glioma mice after treatment with saline, taxol, PTX/PMs, and PTX/Aβ-CN-PMs. C CLSM images of brain sections from orthotopic glioma mice of Cou-6/PMs and Cou-6/Aβ-CN-PMs. Blue, cell nuclei stained with DAPI; Green, Cou-6/PMs and Cou-6/Aβ-CN-PMs; N, normal brain sections; T, glioma section; Red line, boundary of the glioma (magnification × 200). D MRI of brain in control group and brains from orthotopic glioma mice after treatment with saline, taxol, PTX/PMs, and PTX/Aβ-CN-PMs. E TUNEL assay of orthotopic glioma tumor tissues isolated from mice treated with saline, taxol, PTX/PMs, and PTX/Aβ-CN-PMs observed by optical microscope (magnification × 100). Scale bar = 200 μm. Brown areas showed apoptosis of tumor cells

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