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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Novel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo

Fig. 6

In vitro cellular uptake on C6 cells. A CLSM observation of C6 cells after treatment with free Cou-6, Cou-6/PMs, Cou-6/Aβ-CN-PMs, rhApoE/Cou-6/Aβ-CN-PMs for 15, 30, 60 and 120 min (magnification × 200), respectively. B, C Quantitative analysis of cellular uptake by flow cytometry after incubation with free Cou-6, Cou-6/PMs, Cou-6/Aβ-CN-PMs, rhApoE/Cou-6/Aβ-CN-PMs for 2 h, respectively. Means ± SD, n = 3; *P < 0.05, **P < 0.01, ***P < 0.001 versus rhApoE/Cou-6/Aβ-CN-PMs group. D, E Quantitative analysis of cellular uptake by flow cytometry after incubation with rhApoE/Cou-6/Aβ-CN-PMs for 15, 30, 60 and 120 min. F Cellular uptake analysis of rhApoE/Cou-6/Aβ-CN-PMs after incubation with different endocytic inhibitors by flow cytometry. Means ± SD, n = 3; *P < 0.05, **P < 0.01, ***P < 0.001 versus the control group without endocytic inhibitors

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Journal of Nanobiotechnology

ISSN: 1477-3155

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