A PTX loaded Aβ-CN-PMs (PTX/Aβ-CN-PMs) were prepared by film-hydration method with sonication. B PTX/Aβ-CN-PMs effectively captured ApoE and the brain targeted ApoE protein corona surrounding PTX/Aβ-CN-PMs crossed the BBB and BBTB, following by endocytosis into glioma cells.