Fig. 2
From: Nanomedicine for increasing the oral bioavailability of cancer treatments
Calculation of the net bioavailability of orally administered therapeutics. Net bioavailability (F) can be extrapolated by calculating the product of the fraction of the drug that overcomes the gastrointestinal tract (GIT) epithelium (fa), the fraction of the drug that is not metabolized in the GIT (FG), and the fraction of the drug that is not metabolized in the liver (FH)