Fig. 9
From: Nanomedicine for increasing the oral bioavailability of cancer treatments
Synthesis and working mechanism of polyplex nanoparticle-coated Salmonellae. A Polyplex nanoparticles are synthesized by complexing plasmid DNA encoding VEGFR2 with the cationic polymer polyethylenimine and used to coat attenuated Salmonella bacteria. B The system is internalized by M-cells and, C after endosomal escape, the expression of VEGFR2 on the surface of these cells can D induce an anti-tumor immune response via T cell activation. The figure was reprinted from Hu Q., Wu M., Fang C., Cheng C., Zhao M., Fang W., Chu P.K., Ping Y., and Tang G. 2015. Engineering nanoparticle-coated bacteria as oral DNA vaccines for cancer immunotherapy. Nano Lett 15(4):2732–9. ACS Publications