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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

Fig. 8

In vivo therapeutic nanoplatform efficacy. a Comparison of tumour tissues extracted from HepG2 tumour-bearing mice after 21d treatment with PBS, DOX, HMON-Tf NPs, Fe-HMON-Tf NPs, DOX@HMON-Tf NPs, DOX@Fe-HMON-PEG NPs or DOX@Fe-HMON-Tf NPs. b Final weights of tumour tissues extracted from HepG2 tumour-bearing mice after 21d treatment with PBS, DOX, HMON-Tf NPs, Fe-HMON-Tf NPs, DOX@HMON-Tf NPs, DOX@Fe-HMON-PEG NPs or DOX@Fe-HMON-Tf NPs. **P < 0.01; ****P < 0.0001, Kruskal–Wallis test. c Time-dependent changes in tumor volumes in HepG2 tumor-bearing mice. Mean ± SD. d Histological analysis of tumour slices stained with H&E and TUNEL after treatment with PBS, DOX, HMON-Tf NPs, Fe-HMON-Tf NPs, DOX@HMON-Tf NPs, DOX@Fe-HMON-PEG NPs or DOX@Fe-HMON-Tf NPs. Scale bar = 100 μm. e Survival rates of HepG2 tumour-bearing mice after 60d. n = 6

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Journal of Nanobiotechnology

ISSN: 1477-3155

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