Fig. 6

In vivo biodistribution and biosafety. a Blood clearance and blood half-life in mice (n = 3, mean ± SD) after i.v. injection of FP NPs at the different time points. b Biodistribution of Pt in mice (n = 3, mean ± SD) after i.v. injection of FP NPs at the different time points. c–l Blood biochemistry and hematological analysis of mice after i.v. injection of FP NPs at the different time points (day 1, day 3 and day 7) including serum albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), white blood cell (WBC), red blood cell (RBC), blood platelet (PLT), hemoglobin (HGB), hematocrit (HCT) and lymphocytes ratio (%LYM) recorded on day 1, day 3 and day 7 (n = 3, mean ± SD). m H&E staining of the major organs (heart, liver, spleen, lung and kidney) of mice to examine the pathological changes treated with NS (control) and FP + US groups. Scale bar:100 μm