Fig. 7

The distribution and anti-cancer activity of PSVII@MCP-CaP in orthotopic drug-resistant colon cancer nude mice. A Fluorescence distribution in various organs and cancer tissue of orthotopic colon cancer mice observed by in vivo bioluminescence imaging (n = 3). B The average relative fluorescence intensity in organs (fluorescence intensity/organ weight) detected by spectrofluorometer. C In vivo bioluminescence imaging of orthotopic drug-resistant colon cancer nude mice. D Semi-quantitative statistical results of fluorescence intensity of orthotopic drug-resistant colon cancer tissue. E Visual images of orthotopic drug-resistant colon cancer tissue. F Tumor volume of orthotopic drug-resistant colon cancer tissue. All data are expressed as means ± SD (n = 5). **p < 0.01 vs Cy7.5-PSVII (12 h); ^##p < 0.01 vs Cy7.5-PSVII (24 h); ^&p < 0.05, ^&&p < 0.01 vs model; ^$p < 0.05, ^$$p < 0.01 vs L-OHP