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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

Fig. 7

In vivo antitumor efficacy of ICG@PM@NP mediated mild-PTT in CT26 tumors. A Schematic diagram of CT26 tumor experimental design. B–H Tumor growth curves of CT26 tumor-bearing mice after the following treatments (n = 5): 1. Vehicle; 2. Vehicle + Laser; 3. ICG@NP; 4. ICG@NP + Laser; 5. PM@NP; 6. ICG@PM@NP; 7. ICG@PM@NP + Laser. I Photo of collected CT26 tumors after various treatments, scale bar = 2 cm. J Weight of collected CT26 tumors on Day 14 (n = 5). K Distal tumor growth curves of CT26 tumor-bearing mice (n = 5). L Weights of excised distal CT26 tumors (n = 5). Statistical analysis was performed via the two-tail Student’s t-test. * p < 0.05; ** p < 0.01; *** p < 0.001

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