Fig. 4

In vivo tumor therapy with Gel-N-ICG in Tgfbr1/Pten 2cKO mice HNSCC. a Schematic of the Tgfbr1/Pten 2cKO mouse model treatments strategy. Tamoxifen was applicated into oral consecutively for 5 days. 5 weeks after application, HNSCC induced mice consecutively treated with various strategies every other day for 15 days. Data present as mean ± SD, n = 5, respectively. b Representative in vivo IR thermal images of 2cKO mice before and after injection with different solutions with a 5-minute exposure to the laser irradiation. c Tumor volume curves over 15 days in different treatment groups. d Body weight change of 2cKO mice in different groups on 15th day after treatment. e Representative ex vivo tumor photo of 2cKO mice before and after treatment. All data points represent as mean ± SD (n = 5)