Fig. 1
Characterization of macrophage membrane-coated porous Se@SiO2 nanospheres. a Schematic diagram of M-Se@SiO2 synthesis. TEM images of b Se@SiO2, c porous Se@SiO2 nanospheres, and d, e M-Se@SiO2. f X-ray diffractometry pattern of Se@SiO2 nanospheres and the standard Se hexagonal phase (JCPDS card No. 06–0362). g Hydrodynamic sizes of M-Se@SiO2 in PBS over 72 h. h Se release from M-Se@SiO2 and porous Se@SiO2 nanospheres in PBS at 37 °C and pH 7.4 over 72 h. i Size and zeta potential of porous Se@SiO2 nanospheres, M-vesicle, and M-Se@SiO2. j Western blots of TLR4, TNFR1, and IL6-R in porous Se@SiO2 nanospheres, M-vesicle, and M-Se@SiO2. k Removal of LPS and proinflammatory cytokines IL-6 and TNF-α by M-Se@SiO2. l Cell biocompatibility was evaluated using CCK-8 after 1 day of culture (*P < 0.05 compared with the control)