A Schematic illustration of the synthetic process for the HA-PTX/let-7a-GNR@MSN nano co-deliverysystem. B Serial targeted delivery and therapeutic mechanism of the HA-PTX/let-7a-GNR@MSN co-delivery nanosystem in the ovarian cancer SKOV3/SKOV3TR cell line and tumor tissues. HA, hyaluronic acid; PTX, paclitaxel; miR, microRNA; let-7a, lethal-7a; GNR, gold nanorod; MSN, mesoporous silica nanoparticle; ROS, reactive oxygen species