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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Mitochondria-targeted accumulation of oxygen-irrelevant free radicals for enhanced synergistic low-temperature photothermal and thermodynamic therapy

Fig. 4

Accumulation of free radicals in mitochondria induced oxidative damage. a The generation of alkyl radicals in MNNG/HOS cells after corresponding treatment. b The relative level of GSH of MNNG/HOS cells after corresponding treatment. c Detection of mitochondrial membrane potential (ΔΨm). d Intracellular ATP levels of MNNG/HOS cells after corresponding treatment. e The effect of various treatment on the expression of Bax and Bcl-2 in MNNG/HOS cells. (Groups included (1) control, (2) PBS + NIR, (3) AIBI + NIR, (4) AHPR + NIR, (5) AHTPR + NIR). f The effect of various treatment on the expression of Cyt-c, cleaved-caspase 9 and cleaved-caspase 3 in MNNG/HOS cells. g Relative protein levels of Cyt-c, cleaved-caspase 9 and cleaved-caspase 3 in MNNG/HOS cells (*P < 0.05, **P < 0.01, ***P < 0.001)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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