Fig. 4

In vivo tumor accumulation and permeation of M-CFN in 4T1 tumor models. A In vivo imaging of DiR-labeled CFN and M-CFN at different time points. B Ex vivo imaging of DiR-labeled CFN and M-CFN in major organs. C Quantified distribution of CTX in major organs from the free CTX-, CFN- and M-CFN-treated groups, *p < 0.05. D Intratumor permeation of DiI-labeled nanovehicles, scale bar, 1 mm. E Imaging analysis of the intratumor permeation by ImageJ software