Fig. 3

Tumor penetration and biodistribution study. A Z-stack scanning showing penetration of nanoparticles (red) in to 3D tumor spheroid. B In vivo biodistribution of nanoparticles in mice with GBM. (n = 3). C Ex vivo biodistribution of nanoparticles in mice with GBM. D Brain distribution of nanoparticles showing brain tumor targeting effects. E Analysis of fluorescence intensity of nanoparticles in major organs. F Distribution of nanoparticles in the brain of GBM-bearing mice after single injection. Brain tumor boundary was highlighted by white dotted line. ** P < 0.01