Fig. 2From: Femtomolar and locus-specific detection of N6-methyladenine in DNA by integrating double-hindered replication and nucleic acid-functionalized MB@Zr-MOFInvestigation of the feasibility of the developed biosensor. A–C Verification of the high selectivity of double-hindered replication towards target m6A DNA by PAGE experiments. The concentrations of all DNA substrates were 1 μM except target. D DPV signals responding to a blank control, b 1 nM target A, and c 1 nM target m6A DNABack to article page