Fig. 6

Anti-tumor effect of MnP@Lip combined with OXA in 4T1 incomplete tumor resection model. A Treatment protocol of MnP@Lip combined with OXA mediated anti-tumor therapy. B and C Tumor growth curves of different treatment group (n = 7). D Tumor weight and E body weight change after receiving treatments. F Immunohistochemical and immunofluorescence analysis of Ki67, CD4⁺ and CD8⁺ T cells in PBS, OXA, OXA + MnCl₂ and OXA + MnP@Lip group, respectively (n = 3). The scale bars are 20 μm, 50 μm and 50 μm, respectively. 1, 2, 3 and 4 represent PBS group, OXA group, OXA + MnCl₂ group, and OXA + MnP@Lip group, respectively. The data of Figure C and Ki67 satisfying normality, thus One-way ANOVA (including Tukey post-hoc test) was applied. The data of Figure D, CD4⁺ and CD8⁺ satisfying non-normality or heterogeneity variance, thus Kruskal–Wallis test (including Bonferroni post-hoc correction) was applied