Scheme 1

An injectable gel system co-loaded with MnP@Lip nanoparticles and OXA for MR imaging and enhanced immunochemotherapy. MnP@Lip nanoparticles exert the MR imaging capability and can activate STING pathway in macrophage and DC. OXA can induce immunogenic cancer cell death and synergistically elicit the immune system with MnP@Lip nanoparticles to prevent tumor recurrence