Fig. 5

Therapeutic result of RL-NP-DOX-ERL in the SCC7 allograft model (n = 4). a Tumor growth graph of the SCC7 allograft model injected with saline, free DOX and ERL, RL-NP-ERL, RL-NP-DOX, and RL-NP-DOX-ERL (*p < 0.05, ***p < 0.001). Black arrows mean the intravenous injection of samples. b Tumor images from the mice sacrificed after 2 weeks. c H&E-stained images of the sliced tumor tissues. d Body weights of the mice measured for 2 weeks. e H&E-stained images of the sliced major organs