Fig. 7
From: Nanomedicine-enabled chemotherapy-based synergetic cancer treatments
a Schematic representation of molecular structures of PUFAylated cabazitaxel prodrug (LTK-CTX) and chlorin e6 prodrug (L-Ce6) and the working mechanism of PSPC nanoassemblies in vivo. b Morphology presentation of the LTK-CTX nanoassemblies (NAs), L-Ce6 NAs, and PSPC NAs. Scale bars, 100 nm. c Confocal imaging of A375 cells stained with DCFH-DA for 30 min after different treatments. d Confocal imaging of A375 cells stained with γ-H2AX (red) and DAPI(blue) in different groups. e Flow cytometry analysis of A375 cell apoptosis treated by varied conditions. f Tumor volume change curves of mice in different groups. g Body weight change of mice in different groups post-administration. h Scheme showing different stages of Dox-PEG-PS@MIL-100 NPs in H2O2 and corresponding size change and PDT assisted tumor penetration. i The tumor volumes change curves of mice