Fig. 8

Nanomedicine-enabled tumor synergistic starvation/chemotherapy based on Gox-mediated glucose glycolysis. a Schematic diagram of the synthesis and use of TG-GV for combination chemo/starvation therapy. b TEM image of TG-GVs. c The release curves of TPZ from TG-GVs solutions with or no glucose addition. d The cell viabilities of 4T1 cells after undergoing various treatments for 24 h. e The recorded tumor volume change in different groups during the treatments. f Schematic of in vivo working mechanism of A/Q4N/GOx@ZIF-8@CM. g, h TEM images of AQ4N/GOx@ZIF-8 and AQ4N/GOx@ZIF-8@CM. i CLSM images of HepG2 cells stained with oxidative stress/hypoxia detection probe after treated by different conditions. Scale bar, 20 μm. j, k Viabilities of LO2 and HepG2 cells after various treatments. l The photographs of tumors tissues. m HIF-1α, VEGF immunohistochemical, and H&E staining images of tumor tissues