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Table 1 Summary of typical chemotherapy-instructed synergized cancer therapy strategies

From: Nanomedicine-enabled chemotherapy-based synergetic cancer treatments

Therapy modality

Chemotherapeutic agents

Adjuvant components

Working mechanism

Refs

Single Chemotherapy

BTZ; DOX; CPT

PVCL-GMA NGs; RGD peptide; CaO2/MnO2;

Enhancing enrichment and penestration of drug in tumor

[22]; [23]; [24]; [28]

Chemotherapy-CDT

DSF; DOX

PVP/Cu-HMSNs; ZIF-8

The nontoxicity-to-toxicity transition of DSF and H2O2-responsive·OH generation

[33]; [34]

Chemotherapy-PTT

DSF; AQ4N

PVP/Cu-HMPBs; CuS Silicene@Silica

PTT-enhanced the release of chemotherapeutic agents and anti-cancer activity

[37]; [38]; [41]

Chemotherapy-PDT

Cabazitaxel; DOX

Ce6; TPABTDCT

PDT-activated the anti-cancer activity of prodrugs

[46]; [47]

Chemotherapy-Starvation therapy

TPZ; AQ4N; DOX

Gox; 2DG

Starvation-sensitized tumor cells to chemo-drugs

[50]; [52]; [55]

Chemotherapy- Immunotherapy

DOX

NLG919; IMDQ

Chemotherapy-induced robust tumoral ICD to activate anti-cancer immunity

[62]; [64]