Fig. 5

Mechanistic role of HPDC NPs in the synergistic hyperthermia and chemotherapy. A The number of SDEGs between control and HPDC NPs + 808 nm laser irradiation groups. B The volcano plot of SDEGs between the control and HPDC NPs + NIR − I laser irradiation samples. Red dots represent upregulated genes and blue dots represent downregulation genes. C Heatmap of the SDEGs associated with cell cycle and apoptosis. Warm orange color indicates the significantly upregulated genes and cold blue color represents the remarkably downregulated genes (fold change (FC) ≥ 2.0 (or − 2.0) and P < 0.05). D GO and E KEGG enrichment pathway analysis of the SDEGs