Fig. 5

A Schematic diagram of tumor penetration with 4T1 MCSs. B 4T1 MCSs were incubated with DIMP at 37 °C for 6 h and observed with laser confocal microscopy. C, D The average fluorescence intensity of ICG and DOX at different depths (Scale bar: 20 μm). E IR thermal imaging of mice treated with ICG and DIMP at different time points the corresponding temperature change F. G In vivo PA imaging of tumor in tumor-bearing mice 24 h after intravenous injection of DIMP. H Changes of PA signal intensity of DOX and ICG in tumor area. I Fluorescence images of 4T1 tumor-bearing mice injected with ICG and DIMP at different time points (tumors were highlighted by red circles), in vivo fluorescence images of tumors and organs (heart, liver, kidney, spleen and lung). J Quantification of the fluorescence intensity of the tumor at different time points. K Quantification of the fluorescence intensity of tumors and organs (heart, liver, kidney, spleen and lung)