Fig. 2
Nanoagonist characterization. a TEM images of NA0, NAc and dNAc. b Hydrodynamic sizes of NA0, NAc and dNAc measured by DLS. c The zeta potential of NA0, NAc and dNAc dispersed in water. d UV–Vis-NIR spectra of solution containing NA0, NAc and dNAc. e Temperature curves of NA0, NAc and dNAc after treatment of NIR-II laser (1 W/cm2) for different time. f Photothermal stability evaluation of NA0, NAc and dNAc after five cycles of laser on/off. g Analysis of ·OH generation via nanoagonists mediated Fenton reaction using TMB as indicator. h Relative ·OH generation of nanoagonists with or without NIR-II laser treatment (1 W/cm2) for 6 min. i Release of cGAMP from dNAc after NIR-II laser treatment (1 W/cm2) for different time